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زیست شناسی::
دولایه فسفولیپیدی
, with phospholipid bilayers with different membrane-forming components.
: One antimicrobial peptide (grami- cidin S) can affect the function of another (gramicidin A or alamethicin) via effects on the phospholipid bilayer.
In the Bechinger model, the insertion of antimicrobial peptides into phospholipid bilayers is assumed to disorganize the hydrocarbon chains of adjacent phospholipid molecules, creating a local thinning of the bilayer and increasing the cross-sectional area per phospholipid molecule.
This gramicidin S-induced destabilization of the phospholipid bilayer is expected to be enhanced with the insertion of additional peptide molecules, and with an increasing trans-membrane potential, as was indeed observed.
Traces representing gA and Alm channel activities in phospholipid bilayers were recorded at filter frequencies 2 and 20 kHz, respec- tively.
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